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spf specific pathogen free cd1 mice  (Charles River Laboratories)

 
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    Charles River Laboratories spf specific pathogen free cd1 mice
    Efficacy of Fc-CHAP-LSN against in vivo formed biofilms and in sepsis model. (A) Catheters with in vivo formed biofilms of S. aureus ATCC 43300 were explanted from <t>CD1</t> mice 3 dpi and treated with either 50 µg/mL or 100 µg/mL Fc-L1-CHAP opt -LSN HEKa for 24 h at 37 °C. Rifampicin (10 µg/mL) was used as comparator. (B) Datapoints represent the biofilm bacterial burden in each catheter (n=6). Horizontal bars indicate the median burden for each group. When burden is below LOQ, half a value of LOQ is assigned for graphical and statistical purposes. Brown Forsythe ANOVA with Welch’s correction (GraphPad Prism) was used to calculate statistical significance against vehicle. dpi: days post infection; LOQ: limit of quantification at 10 CFU/catheter. (C) Lysin efficacy in mouse IV sepsis: Immunocompetent male CD1 mice were challenged with 3.23 × 10 7 CFU/mouse of S. aureus NCTC 8178, IV. Lysins were administered IV, twice (1 hpi and 25 hpi) at dose of either 100 µg/mouse or 500 µg/mouse. Vancomycin (Van) was dosed at 25 mg/kg, IV, q12 h, starting from 1 hpi. (D) Points on the graph represent CFU counts in individual mice (n=6), with horizontal lines indicating median CFU burden and interquartile range. Open circles indicate animals that needed to be terminated before planned endpoint due to clinical symptoms. Brown-Forsythe ANOVA with Welch’s correction was used to calculate the significance compared to vehicle group on log transformed data, with P values indicated in the graph. hpi: hours post infection; CFU: colony forming units; LOQ: limit of quantification at 54 CFU/g; For graphical and statistical purposes, values under LOQ were assigned half of the LOQ value.
    Spf Specific Pathogen Free Cd1 Mice, supplied by Charles River Laboratories, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/spf+specific+pathogen+free+cd1+mice/bio_rxiv__64898__2026__05__13__724763-186-0-13?v=Charles+River+Laboratories
    Average 86 stars, based on 1 article reviews
    spf specific pathogen free cd1 mice - by Bioz Stars, 2026-08
    86/100 stars

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    1) Product Images from "A chimeric, half-life extended lysin with a unique mode of action"

    Article Title: A chimeric, half-life extended lysin with a unique mode of action

    Journal: bioRxiv

    doi: 10.64898/2026.05.13.724763

    Efficacy of Fc-CHAP-LSN against in vivo formed biofilms and in sepsis model. (A) Catheters with in vivo formed biofilms of S. aureus ATCC 43300 were explanted from CD1 mice 3 dpi and treated with either 50 µg/mL or 100 µg/mL Fc-L1-CHAP opt -LSN HEKa for 24 h at 37 °C. Rifampicin (10 µg/mL) was used as comparator. (B) Datapoints represent the biofilm bacterial burden in each catheter (n=6). Horizontal bars indicate the median burden for each group. When burden is below LOQ, half a value of LOQ is assigned for graphical and statistical purposes. Brown Forsythe ANOVA with Welch’s correction (GraphPad Prism) was used to calculate statistical significance against vehicle. dpi: days post infection; LOQ: limit of quantification at 10 CFU/catheter. (C) Lysin efficacy in mouse IV sepsis: Immunocompetent male CD1 mice were challenged with 3.23 × 10 7 CFU/mouse of S. aureus NCTC 8178, IV. Lysins were administered IV, twice (1 hpi and 25 hpi) at dose of either 100 µg/mouse or 500 µg/mouse. Vancomycin (Van) was dosed at 25 mg/kg, IV, q12 h, starting from 1 hpi. (D) Points on the graph represent CFU counts in individual mice (n=6), with horizontal lines indicating median CFU burden and interquartile range. Open circles indicate animals that needed to be terminated before planned endpoint due to clinical symptoms. Brown-Forsythe ANOVA with Welch’s correction was used to calculate the significance compared to vehicle group on log transformed data, with P values indicated in the graph. hpi: hours post infection; CFU: colony forming units; LOQ: limit of quantification at 54 CFU/g; For graphical and statistical purposes, values under LOQ were assigned half of the LOQ value.
    Figure Legend Snippet: Efficacy of Fc-CHAP-LSN against in vivo formed biofilms and in sepsis model. (A) Catheters with in vivo formed biofilms of S. aureus ATCC 43300 were explanted from CD1 mice 3 dpi and treated with either 50 µg/mL or 100 µg/mL Fc-L1-CHAP opt -LSN HEKa for 24 h at 37 °C. Rifampicin (10 µg/mL) was used as comparator. (B) Datapoints represent the biofilm bacterial burden in each catheter (n=6). Horizontal bars indicate the median burden for each group. When burden is below LOQ, half a value of LOQ is assigned for graphical and statistical purposes. Brown Forsythe ANOVA with Welch’s correction (GraphPad Prism) was used to calculate statistical significance against vehicle. dpi: days post infection; LOQ: limit of quantification at 10 CFU/catheter. (C) Lysin efficacy in mouse IV sepsis: Immunocompetent male CD1 mice were challenged with 3.23 × 10 7 CFU/mouse of S. aureus NCTC 8178, IV. Lysins were administered IV, twice (1 hpi and 25 hpi) at dose of either 100 µg/mouse or 500 µg/mouse. Vancomycin (Van) was dosed at 25 mg/kg, IV, q12 h, starting from 1 hpi. (D) Points on the graph represent CFU counts in individual mice (n=6), with horizontal lines indicating median CFU burden and interquartile range. Open circles indicate animals that needed to be terminated before planned endpoint due to clinical symptoms. Brown-Forsythe ANOVA with Welch’s correction was used to calculate the significance compared to vehicle group on log transformed data, with P values indicated in the graph. hpi: hours post infection; CFU: colony forming units; LOQ: limit of quantification at 54 CFU/g; For graphical and statistical purposes, values under LOQ were assigned half of the LOQ value.

    Techniques Used: In Vivo, Infection, Transformation Assay



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    Efficacy of Fc-CHAP-LSN against in vivo formed biofilms and in sepsis model. (A) Catheters with in vivo formed biofilms of S. aureus ATCC 43300 were explanted from <t>CD1</t> mice 3 dpi and treated with either 50 µg/mL or 100 µg/mL Fc-L1-CHAP opt -LSN HEKa for 24 h at 37 °C. Rifampicin (10 µg/mL) was used as comparator. (B) Datapoints represent the biofilm bacterial burden in each catheter (n=6). Horizontal bars indicate the median burden for each group. When burden is below LOQ, half a value of LOQ is assigned for graphical and statistical purposes. Brown Forsythe ANOVA with Welch’s correction (GraphPad Prism) was used to calculate statistical significance against vehicle. dpi: days post infection; LOQ: limit of quantification at 10 CFU/catheter. (C) Lysin efficacy in mouse IV sepsis: Immunocompetent male CD1 mice were challenged with 3.23 × 10 7 CFU/mouse of S. aureus NCTC 8178, IV. Lysins were administered IV, twice (1 hpi and 25 hpi) at dose of either 100 µg/mouse or 500 µg/mouse. Vancomycin (Van) was dosed at 25 mg/kg, IV, q12 h, starting from 1 hpi. (D) Points on the graph represent CFU counts in individual mice (n=6), with horizontal lines indicating median CFU burden and interquartile range. Open circles indicate animals that needed to be terminated before planned endpoint due to clinical symptoms. Brown-Forsythe ANOVA with Welch’s correction was used to calculate the significance compared to vehicle group on log transformed data, with P values indicated in the graph. hpi: hours post infection; CFU: colony forming units; LOQ: limit of quantification at 54 CFU/g; For graphical and statistical purposes, values under LOQ were assigned half of the LOQ value.
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    Efficacy of Fc-CHAP-LSN against in vivo formed biofilms and in sepsis model. (A) Catheters with in vivo formed biofilms of S. aureus ATCC 43300 were explanted from CD1 mice 3 dpi and treated with either 50 µg/mL or 100 µg/mL Fc-L1-CHAP opt -LSN HEKa for 24 h at 37 °C. Rifampicin (10 µg/mL) was used as comparator. (B) Datapoints represent the biofilm bacterial burden in each catheter (n=6). Horizontal bars indicate the median burden for each group. When burden is below LOQ, half a value of LOQ is assigned for graphical and statistical purposes. Brown Forsythe ANOVA with Welch’s correction (GraphPad Prism) was used to calculate statistical significance against vehicle. dpi: days post infection; LOQ: limit of quantification at 10 CFU/catheter. (C) Lysin efficacy in mouse IV sepsis: Immunocompetent male CD1 mice were challenged with 3.23 × 10 7 CFU/mouse of S. aureus NCTC 8178, IV. Lysins were administered IV, twice (1 hpi and 25 hpi) at dose of either 100 µg/mouse or 500 µg/mouse. Vancomycin (Van) was dosed at 25 mg/kg, IV, q12 h, starting from 1 hpi. (D) Points on the graph represent CFU counts in individual mice (n=6), with horizontal lines indicating median CFU burden and interquartile range. Open circles indicate animals that needed to be terminated before planned endpoint due to clinical symptoms. Brown-Forsythe ANOVA with Welch’s correction was used to calculate the significance compared to vehicle group on log transformed data, with P values indicated in the graph. hpi: hours post infection; CFU: colony forming units; LOQ: limit of quantification at 54 CFU/g; For graphical and statistical purposes, values under LOQ were assigned half of the LOQ value.

    Journal: bioRxiv

    Article Title: A chimeric, half-life extended lysin with a unique mode of action

    doi: 10.64898/2026.05.13.724763

    Figure Lengend Snippet: Efficacy of Fc-CHAP-LSN against in vivo formed biofilms and in sepsis model. (A) Catheters with in vivo formed biofilms of S. aureus ATCC 43300 were explanted from CD1 mice 3 dpi and treated with either 50 µg/mL or 100 µg/mL Fc-L1-CHAP opt -LSN HEKa for 24 h at 37 °C. Rifampicin (10 µg/mL) was used as comparator. (B) Datapoints represent the biofilm bacterial burden in each catheter (n=6). Horizontal bars indicate the median burden for each group. When burden is below LOQ, half a value of LOQ is assigned for graphical and statistical purposes. Brown Forsythe ANOVA with Welch’s correction (GraphPad Prism) was used to calculate statistical significance against vehicle. dpi: days post infection; LOQ: limit of quantification at 10 CFU/catheter. (C) Lysin efficacy in mouse IV sepsis: Immunocompetent male CD1 mice were challenged with 3.23 × 10 7 CFU/mouse of S. aureus NCTC 8178, IV. Lysins were administered IV, twice (1 hpi and 25 hpi) at dose of either 100 µg/mouse or 500 µg/mouse. Vancomycin (Van) was dosed at 25 mg/kg, IV, q12 h, starting from 1 hpi. (D) Points on the graph represent CFU counts in individual mice (n=6), with horizontal lines indicating median CFU burden and interquartile range. Open circles indicate animals that needed to be terminated before planned endpoint due to clinical symptoms. Brown-Forsythe ANOVA with Welch’s correction was used to calculate the significance compared to vehicle group on log transformed data, with P values indicated in the graph. hpi: hours post infection; CFU: colony forming units; LOQ: limit of quantification at 54 CFU/g; For graphical and statistical purposes, values under LOQ were assigned half of the LOQ value.

    Article Snippet: SPF (specific pathogen free) CD1 mice used in this work were supplied by Charles River Laboratories (Margate, UK).

    Techniques: In Vivo, Infection, Transformation Assay